5/21/2025
Last update
5/21/2025
Research Authors
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
200 mg
â€
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
â€
Top Medical Research Studies
9
We explored the impact of Coenzyme Q10 (CoQ10) on knee pain and cartilage health using a rat model of osteoarthritis (OA). Our investigation involved inducing OA in rats through an injection of monosodium iodoacetate into the knee joint. Subsequently, we administered CoQ10 orally starting on the fourth day after the injection.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
8
This study examined the effects of coenzyme Q10 (CoQ10) and ischemic preconditioning (IPC) on knee pain following total knee arthroplasty (TKA). We enrolled 44 patients in four groups: a control group, a group receiving CoQ10, a group undergoing IPC, and a group that received both treatments.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
Most Useful Reviews
9
Joint pain relief
6 people found this helpful
I have been taking COQ10 for at least six months before ordering it from you. Doctors often neglect to mention that if you're on cholesterol medication, you need to replenish with this supplement to alleviate joint pain, ideally 200 mg daily.
9
Effective for cramps
2 people found this helpful
This product works wonderfully for relieving leg cramps and pain caused by statins.
9
Pain alleviation
1 people found this helpful
Despite taking a small dose of cholesterol medication, I experienced significant muscle leg pain. However, after I began using this product alongside my medication, the pain disappeared.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
We explored the impact of Coenzyme Q10 (CoQ10) on knee pain and cartilage health using a rat model of osteoarthritis (OA). Our investigation involved inducing OA in rats through an injection of monosodium iodoacetate into the knee joint. Subsequently, we administered CoQ10 orally starting on the fourth day after the injection.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
8
This study examined the effects of coenzyme Q10 (CoQ10) and ischemic preconditioning (IPC) on knee pain following total knee arthroplasty (TKA). We enrolled 44 patients in four groups: a control group, a group receiving CoQ10, a group undergoing IPC, and a group that received both treatments.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Joint pain relief
6 people found this helpful
I have been taking COQ10 for at least six months before ordering it from you. Doctors often neglect to mention that if you're on cholesterol medication, you need to replenish with this supplement to alleviate joint pain, ideally 200 mg daily.
9
Effective for cramps
2 people found this helpful
This product works wonderfully for relieving leg cramps and pain caused by statins.
9
Pain alleviation
1 people found this helpful
Despite taking a small dose of cholesterol medication, I experienced significant muscle leg pain. However, after I began using this product alongside my medication, the pain disappeared.
9
Knee pain support
This has helped with my knee pain.
Frequently Asked Questions
9
Joint pain relief
6 people found this helpful
I have been taking COQ10 for at least six months before ordering it from you. Doctors often neglect to mention that if you're on cholesterol medication, you need to replenish with this supplement to alleviate joint pain, ideally 200 mg daily.
9
Knee pain support
This has helped with my knee pain.
9
Pain alleviation
1 people found this helpful
Despite taking a small dose of cholesterol medication, I experienced significant muscle leg pain. However, after I began using this product alongside my medication, the pain disappeared.
9
Effective for cramps
2 people found this helpful
This product works wonderfully for relieving leg cramps and pain caused by statins.
8
This study examined the effects of coenzyme Q10 (CoQ10) and ischemic preconditioning (IPC) on knee pain following total knee arthroplasty (TKA). We enrolled 44 patients in four groups: a control group, a group receiving CoQ10, a group undergoing IPC, and a group that received both treatments.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
9
We explored the impact of Coenzyme Q10 (CoQ10) on knee pain and cartilage health using a rat model of osteoarthritis (OA). Our investigation involved inducing OA in rats through an injection of monosodium iodoacetate into the knee joint. Subsequently, we administered CoQ10 orally starting on the fourth day after the injection.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
References
- Leurcharusmee P, Sawaddiruk P, Punjasawadwong Y, Sugundhavesa N, Klunklin K, et al. CoenzymeQ10 and Ischemic Preconditioning Potentially Prevent Tourniquet-Induced Ischemia/Reperfusion in Knee Arthroplasty, but Combined Pretreatment Possibly Neutralizes Their Beneficial Effects. Antioxidants (Basel). 2022;11. 10.3390/antiox11020419
- Lee J, Hong YS, Jeong JH, Yang EJ, Jhun JY, et al. Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PLoS One. 2013;8:e69362. 10.1371/journal.pone.0069362
